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Abstract Small molecules play important roles in a variety of biological processes such as metabolism, cell signaling and enzyme regulation, and can serve as valuable biomarkers for human diseases. Moreover, they are essential to drug discovery and development, and are important targets for environmental monitoring and food safety. Due to the size incompatibility, small molecule transport is difficult to be monitored with a nanopore. A popular strategy for nanopore detection of small molecules is to introduce a molecular probe as a ligand (or recognition element) and rely on their effect on the ligand transport. One limitation for this sensing strategy is that the probe molecule needs to have a slightly smaller size than the nanopore constriction or can be easily unfolded or unzipped through the pore. Herein, by taking advantage of replacement and complexation chemical interactions, a generic approach is reported for detection of small molecules by using large biomolecules with well‐defined stable 3D structures such as aptamers as recognition elements. Given the versatile use of aptamers as capture agents for a wide variety of species, the developed nanopore sensing strategy should find applications in many fields. 

Keeping users engaged with mHealth applications is important but difficult to achieve. We describe the development of a smartphone-based application designed to promote health and wellness in church communities, along with mechanisms explicitly designed to maintain engagement. We evaluated religiously tailored techno-spiritual engagement mechanisms, including a prayer posting wall, pastor announcements, an embodied conversational agent for dialogue-based scriptural reflections and health coaching, and tailored push notifications. We conducted a four-week pilot study with 25 participants from two churches, measuring high levels of participant acceptance and satisfaction with all features of the application. Engagement with the app was higher for users considered to be more religious and correlated with the number of notifications received. Our findings demonstrate that our tailored mechanisms can increase engagement with an mHealth app 

To overcome the effect of other components of complicated biological samples on nanopore stochastic sensing, displacement chemical reaction was utilized to selectively extract the target nucleic acid from whole blood. Given its simplicity and high sensitivity for detecting nucleic acids, our developed displacement chemistry-based nanopore sensing strategy offers the potential for fieldable/point-of-care diagnostic applications.